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KMID : 1143620150190020102
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Korean Journal of Nuclear Medicine Technology
2015 Volume.19 No. 2 p.102 ~ p.108
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Ultrasensitive serum thyroglobulin the usefulness of evaluation
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Lee Sun-Ho
Cho Eun-Bit
Shin Young-Kyun
Lee Young-Ji
Yoon Seon-Hee
Kim Nyun-Ok
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Abstract
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Purpose : Serum Thyroglobulin measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients. Thyroglobulin is Normal thyroid tissue, or thyroid cancer tissue produced only. Thyroid hormone to a halt without Tg differentiation of thyroid cancer recurrence just by measuring how to decide whether there was increasing expectations if I can do it instead. Therefore, in excellent sensitivity Tg new inspection of the functional sensitivity by measuring the looked to evaluate the usefulness of reagents. Thyroidectomy is measuring the numbers Tg (total thyroidectomy) remaining thyroid ablation and radioactive iodine (radioactive iodine remnant ablation, RRA) DTC in patients being diagnosed with or help predict the remaining early detection of thyroid cancer recurrence.
Materials and Methods : Agent that I'm currently using Tg of the measurements of low clinical specimen for a second drainage of the three (0.08 0.17, 0.98, ng/mL) within the scope of the dilute magnification (2, 4, 8, 16, 32 times) by dilute
Intraassy (n=10) and Interassay (n=10) out in no time. Concentration value according to the coefficient of variation and the mean and standard deviation of each measurement (Coefficient of variation, CV) the absolute value of the measured values that corresponds to 20 percent target a coefficient of variation of CV Find the value of the concentration of the functional sensitivity measurement did. Also, analytical sensitivity with recovery rates, Dilution test inspections, and interrelationship, compared.
Results : Sensitivity is an excellent analytical sensitivity within the prosecutor kit Tg 0.006 ng/mL, and core analytical sensitivity, conducted by the 0.006 ng/mL to same conclusion. Be rather high to 142 percent recovery rate was 60 to measurement and functional sensitivity, 0.01766 ng/mL(Intraassay n=10) was measured at. CBC is relatively good correlation as (R2 =0.949) the correlation.
Conclusion : Recently ultrasensitive thyroglobulin this clinically important indicators of the previous kit and demands are
lower than sensitivity to the measurement results. Therefore, ultrasensitive thyroglobulin test is correlated that
there would be useful in value in nuclear medicine the thyroid gland.
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KEYWORD
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Ultrasensitive thyroglobulin, Functional sensitivity, DTC
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